ECTOSEAL P2G™ POWDER (30-5217)


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EctoSeal P2G™
The transforming wound care base that produces a unique tissue-protective, microbiome-supportive film.

Overview

Developed using extremolytes and a prebiotic, EctoSeal P2G quickly transforms from a powder to a hydrogel when moistened, enabling easy application to any type of wound.

The hydrogel forms a protective film that seamlessly adheres to the wound, improving moisturization and active pharmaceutical ingredients (APIs) contact time — characteristics known to be ideal for wound care preparations.

Its ability to quickly transform from a protective film back to a hydrogel when remoistened makes wound cleaning easier and less painful for patients. And because EctoSeal P2G was developed using natural sources, it leaves no chemical residue.1-3

The versatility of EctoSeal P2G allows integration and use with a wide range of APIs, delivering personalized medicine tailored to a patient’s specific condition and need.

Optimized to Protect & Support the Skin’s Microbiome

  • Protective Ingredients
    Ectoin and trehalose, both classified as extremolytes, are two naturally occurring compounds with unique properties that enable them to protect tissues under extreme conditions and in harsh environments by enhancing moisture retention. Their unique protective and moisturizing properties are ideal for wound preparations.4-6
  • Microbiome Enhancing
    Inulin, a prebiotic, serves to nourish and support development of beneficial microflora within the skin’s environment. In addition, inulin contains a natural, soluble fiber that forms an aqueous film on the skin to further protect, hydrate and support the skin’s microbiome.7
  • Improved Solubility
    Cyclodextrin, a cyclic oligosaccharide commonly used in pharmaceutical formulations, helps the solubility and dispersibility of APIs.

Options for EctoSeal P2G Topical Dosage Forms

  • Powder for Reconstitution
    Powder is mixed with API(s) and brought to volume (q.s.) with maltodextrin. The dispensed API/powder compound is mixed with purified water, sterile water or saline at time of use to create a hydrogel, which is then applied to the affected area.
  • Hydrogel
    Powder is mixed with API(s), an appropriate wetting agent, preservative and purified water, and dispensed as a hydrogel.
  • Powder
    Powder is mixed with API(s). The dispensed API/powder compound is directly sprinkled into the wound. If wound presents with a moist environment due to exudate, the powder will absorb the moisture and, once dried, form a protective shield. For dry wound environments, powder is sprinkled onto the wound and may be moistened with purified water, sterile water or saline.

EctoSeal P2G Key Benefits

  • Versatile topical base for use in anhydrous powder and aqueous hydrogel formulas.
  • Quickly transforms from powder to hydrogel when moistened.
  • Developed using natural ingredients renowned for their tissue-protecting properties.
  • Forms a delicate, protective film with exceptional API adhesion, which is ideal for wound care preparations.
  • Maintains optimized moisture levels conducive to wound healing.
  • May support and protect the skin’s microbiome.
  • Reverts from film to gel when remoistened to simplify wound cleaning and ease patient discomfort.
  • Leaves no chemical residue due to its natural ingredients.
  • Provides integration and use with a wide range of APIs to accommodate unique patient needs. Can be used in animal wounds.

Related Specialties

  • Internal medicine/family practice
  • Wound care specialists
  • Surgery
  • Hospice
  • Geriatrics
  • Dermatology
  • Pediatrics
  • Podiatry
  • Veterinary practice

Formulated Without*

  • Gluten
  • Casein
  • Coconut
  • Crustacean
  • Egg
  • Fish
  • Gliadin
  • Hazelnut
  • Almond
  • Macadamia nut
  • Milk
  • Peanut
  • Pecan
  • Soy
  • Walnut
  • Sesame

*EctoSeal P2G is not vegan.

Frequently Asked Questions

Are EctoSeal P2G preparations for wounds only available with a prescription?

Yes. EctoSeal P2G was designed to work with antibiotics, antifungals and wound care formulations.

Can EctoSeal P2G be used for oral mucosa?

Yes. EctoSeal P2G can be used in any type of wound, including oral mucosa and surgical wounds.

Can EctoSeal P2G be used on animals?

Yes. EctoSeal P2G can be used in veterinary practices for animal patients.

Are there alternative wetting agents to Base C?

Yes. Alternative wetting agents for use with EctoSeal P2G include propylene glycol, diethylene glycol monoethyl ether, medium chain triglycerides (MCT) oil and glycerin. However, when using an alternate wetting agent, we found that friction increased during the EMP mixing, which resulted in a loud noise. If that occurs, we suggest mixing the preparation by hand vigorously in a beaker using a glass stir rod and milling if necessary. If milling is required, the preparation must be remixed before packaging.

Why do medicine cups need to be rinsed and cleaned immedately?

The adhesive properties of EctoSeal P2G hydrogel preparations may develop a type of “gluing” effect that can be challenging to remove. Rinsing the medicine cup immediately after use helps remove potential challenges.

How do the adhesive properties affect ointment mills?

The adhesive properties of EctoSeal P2G can begin forming a film, which may be more difficult to remove if allowed to stand. Therefore, we suggest immediately cleaning the ointment mill with soap and water.

Do the adhesive properties affect EMP jars and lids for hydrogel preparations?

Yes. If any hydrogel preparation remains on the jar’s threads or on the lid, it can make opening the jar more difficult. It can be opened but will require extra effort. We recommend cleaning the lid and jar’s threads before dispensing and advising patients to keep the threads clean after each use. In addition, some preparations stored in EMP jars may cause “sticking” around the edges of the EMP bottom plate, so more force may be required to eject the contents from the EMP jar when not in daily use.

Always make sure you have checked the PCCA Formula Database and are following the most up-to-date version of a formula, as changes are continuously made to existing formulations to provide the highest quality. The formulas and/or statements listed are provided for educational purposes only. They are compounding ideas that have commonly been requested by physicians and have not been evaluated by the Food and Drug Administration. Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

References

  1. Gosai, H., Patel, P., Trivedi, H., Joshi, U. (2021). Role of Biodegradable Polymer-Based Biomaterials in Advanced Wound Care. In: Kumar, P., Kothari, V. (eds) Wound Healing Research. Springer, Singapore. https://doi.org/10.1007/978-981-16-2677-7_18
  2. Nguyen, H. M., Ngoc Le, T. T., Nguyen, A. T., et al. (2023). Biomedical materials for wound dressing: recent advances and applications. RSC Advances, 13(8), 5509–5528. https://doi.org/10.1039/d2ra07673j
  3. Niculescu, A. G., & Grumezescu, A. M. (2022). An Up-to-Date Review of Biomaterials Application in Wound Management. Polymers, 14(3), 421. https://doi.org/10.3390/polym14030421
  4. Ma, Z., Wu, C., Zhu, L., et al. (2022). Bioactivity profiling of the extremolyte ectoine as a promising protectant and its heterologous production. 3 Biotech, 12(12), 331. https://doi.org/10.1007/s13205-022-03370-5
  5. Liu, N., Cui, T., Gao, X., Zhu, D., & Xing, J. (2022). Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 38(6), 2153–2168. https://pubmed.ncbi.nlm.nih.gov/35786469/
  6. Spindler, R., Rosenhahn, B., Hofmann, N., et al. (2012). Video analysis of osmotic cell response during cryopreservation. Cryobiology, 64(3), 250–260. https://doi.org/10.1016/j.cryobiol.2012.02.008
  7. Woolery-Lloyd, H., Andriessen, A., Day, D., Gonzalez, N., Green, L., Grice, E., & Henry, M. (2023). Review of the microbiome in skin aging and the effect of a topical prebiotic containing thermal spring water. Journal of Cosmetic Dermatology , 22(1), 96–102. https://doi.org/10.1111/jocd.15464
  • Department of Transportation (DOT); In accordance with DOT

Caution: *NOTICE: DESICCANTS INSIDE* *HYGROSCOPIC* - FOR USE AS AN EXCIPIENT

Test Specification
DESCRIPTION WHITE POWDER
SOLUBILITY SOLUBLE AT 20% IN ROOM TEMPERATURE WATER (GIVING A THICK GEL)