UNIFLOW (30-5264)



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Changing the Game for T3/T4 Compounding.

UniFlow is an excipient powder base optimized for compounding thyroid hormones T3 and T4. With its game-changing design, UniFlow can help pharmacies reduce compounding time and enhance stability when compounding T3 and T4 powder triturations and when used in capsule compounding.

Key Benefits & Features

  • Superior flowability: Consistent flow reduces irregularities in the compounding process, allowing for easier mixing.  
  • Exceptional uniformity: Proven consistent drug distribution across mortar & pestle, FlackTekTM and RAMTM mixing methods.
  • Enhanced stability: Low-moisture design protects sensitive APIs from degradation caused by environmental moisture.
  • More consistent potency testing: Improved content uniformity and stability increase potency testing success rates.
  • Faster preparation: Cuts powder trituration compounding time by, on average, 50% (when using the mortar and pestle method), resulting in reduced costs due to better material utilization and efficient use of technicians’ time.

Watch our Senior Formulation Specialist create a T3/T4 trituration with UniFlow in nearly half the time it takes using microcrystalline cellulose.

Resources

Common APIs

  • Liothyronine sodium (T3)
  • Levothyroxine sodium (T4)

Ideal in formulations for

  • Thyroid hormone therapy (T3/T4)
  • Hygroscopic APIs

Formulated without

  • Wheat
  • Milk
  • Egg
  • Soybean
  • Fish
  • Crustacean
  • Peanuts
  • Tree nuts

    • Gluten-free. Suitable for vegans.

Ingredients

  • Microcrystalline Cellulose NF
  • Anhydrous Dibasic Calcium Phosphate USP
  • Sodium Stearyl Fumarate NF
  • Magnesium Stearate NF
  • Corn Starch NF
  • Pregelatinized Starch NF
  • Colloidal Silicon Dioxide NF

Frequently Asked Questions

PCCA developed UniFlow specifically to meet the needs of compounding highly potent, low-dose APIs such as T3 and T4. It delivers consistent trituration uniformity, reducing variability in results, while incorporating advancements in excipient technology to enhance moisture control and powder flow. This combination ensures reliability, precision and ease of use in preparing thyroid hormone formulations.

UniFlow tackles key challenges in compounding low-dose APIs like T3 and T4, including content uniformity failures from inconsistent API distribution, moisture instability that can degrade sensitive hormones, and costly retesting due to inconsistent trituration batches.

During beta testing, compounders were able to compound T3/T4 triturations approximately 50 percent faster when using a mortar and pestle.

See PCCA's formulation database for all available UniFlow formulas. All formulas are developed by a team of scientists and pharmacists in PCCA’s Formulations Lab. Documentation is made of all procedures, calculations and key findings.

UniFlow is also an ideal capsule filler for hygroscopic APIs, such as betahistine dihydrochloride.

UniFlow is specifically designed for T3 and T4 formulations, delivering superior flowability, reliable content uniformity and advanced moisture protection — particularly valuable for hygroscopic APIs. Both UniFlow and LoxOral effectively address static challenges, but UniFlow excels when high flow and moisture control are critical.

  • Not applicable

Caution: *NOTICE: DESICCANTS INSIDE* - FOR USE AS AN EXCIPIENT

Test Specification
DESCRIPTION WHITE POWDER, ODORLESS TO MILD CHARACTERISTIC ODOR
LOSS ON DRYING <=6.0 %
PARTICLE SIZE COMPLIES PER PCCA SPECIFICATION
SOLUBILITY INSOLUBLE IN WATER