Enhanced Permeation for Drugs with High Molecular Weight
Lipoderm HMW is a base with a patented delivery system that is designed to deliver drugs with high molecular weights into and through the skin.
Lipoderm HMW works with solvents commonly used by compounding pharmacies, such as propylene glycol, ethoxy diglycol, DMSO, purified water, glycerin and alcohol. The semi-clear emulsion gives it an elegant cosmetic feel. It is very easy to work with and is formulated without parabens and propylene glycol. However, Lipoderm HMW is not stable with high salt-load drugs.
Lipoderm HMW could potentially be an appropriate choice for any high-molecular-weight and water-stable drug needed in compounding medications for patients with autism. Lipoderm HMW is formulated without lecithin, phospholipids and eggs.
Validation
PCCA conducted a study with Lipoderm HMW using radio-labeled human insulin, which has a high molecular weight (over 5,500 daltons), to test its absorption through human trunk skin. (The skin of the trunk is considered the hardest to penetrate, aside from the heel of your foot, since it is thick skin.) The study results showed that Lipoderm HMW was able to deliver insulin into and through human skin, in vitro.